Predictive role of anti-gp210 and anticentromere antibodies in long-term outcome of primary biliary cirrhosis.

Abstract

Because some of the autoreactive T-cell clones specific for human PDC-E2 cross-react to mimicry peptides having an EIExDK motif derived from nuclear antigens such as human gp210 and sp100, we studied the clinical significance of antinuclear antibodies (ANA) in primary biliary cirrhosis (PBC) patients registered to the National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ). We found that there are two different types of progression in PBC; one is a hepatic failure-type progression which is represented by positive anti-gp210 antibodies and the other is a portalhypertension-type progression which is represented by positive anticentromere antibodies. We discuss the predictive role of these ANA in the long-term outcome of PBC and the mechanisms by which two different PBC progression types occur based on molecular mimicry and aberrant expression of nuclear antigens.

• Authors: Minoru Nakamura, Atsumasa Komori, Masahiro Ito, Hisayoshi Kondo, Yoshihiro Aiba, Kiyoshi Migita, Shinya Nagaoka, Kazuyuki Ohata, Koji Yano, Seigo Abiru, Manabu Daikoku, Hiroshi Yatsuhashi, Shinji Shimoda, Hiromi Ishibashi
• Journal: Hepatology research : the official journal of the Japan Society of Hepatology (Hepatol Res) Vol. 37 Suppl 3 Pg. S412-9 (Oct 2007) ISSN: 1386-6346 [Print] Netherlands
• PMID: 17931196 (Publication Type: Journal Article)