Abstract | BACKGROUND: METHODS: We measured sex hormones in longitudinally collected samples of 180 postmenopausal women, 91 randomized to 17beta-estradiol and 89 to placebo, in the Estrogen in the Prevention of Atherosclerosis Trial. Repeated measures of sex hormone levels were tested for an association with carotid artery intima-media thickness (CIMT), which was also assessed longitudinally over 2 yr. RESULTS: CONCLUSION:
Estrogen and SHBG are associated with reduced subclinical atherosclerosis progression in healthy postmenopausal women. These associations are partially mediated by their beneficial effects on lipids. Among women taking estradiol, the most beneficial hormone profile for CIMT progression was increased free estradiol and SHBG with concomitant decreased free testosterone.
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Authors | Roksana Karim, Howard N Hodis, Frank Z Stanczyk, Rogerio A Lobo, Wendy J Mack |
Journal | The Journal of clinical endocrinology and metabolism
(J Clin Endocrinol Metab)
Vol. 93
Issue 1
Pg. 131-8
(Jan 2008)
ISSN: 0021-972X [Print] United States |
PMID | 17925335
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural)
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Chemical References |
- Blood Glucose
- Insulin
- Sex Hormone-Binding Globulin
- Triglycerides
- Estrone
- Testosterone
- Estradiol
- Cholesterol
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Topics |
- Atherosclerosis
(blood)
- Blood Glucose
(metabolism)
- Carotid Arteries
(diagnostic imaging, pathology)
- Cholesterol
(blood)
- Disease Progression
- Double-Blind Method
- Estradiol
(administration & dosage, blood)
- Estrogen Replacement Therapy
(methods)
- Estrone
(blood)
- Female
- Humans
- Insulin
(blood)
- Longitudinal Studies
- Middle Aged
- Sex Hormone-Binding Globulin
(agonists)
- Testosterone
(blood)
- Triglycerides
(blood)
- Ultrasonography
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