Abstract | OBJECTIVES: To evaluate the rate of adverse respiratory events and vomiting among ED patients undergoing procedural sedation with propofol. METHODS: This was a prospective, observational series of patients undergoing procedural sedation. Titrated i.v. propofol was administered via protocol. Fasting status was recorded. RESULTS: Four hundred patients undergoing sedation were enrolled. Of these 282 (70%, 95% confidence interval [CI] 66-75%) had eaten or drunken within 6 and 2 h, respectively. Median fasting times from a full meal, snack or drink were 7 h (interquartile range [IQR] 5-9 h), 6 h (IQR 4-8 h) and 4 h (IQR 2-6 h), respectively. Overall a respiratory event occurred in 86 patients (22%, 95% CI 18-26%). An airway intervention occurred in 123 patients (31%, 95% CI 26-35%). In 111 cases (90%, 95% CI 60-98%) basic airway manoeuvres were all that was required. No patients were intubated. Two patients vomited (0.5%, 95% CI 0.0-1.6%), one during sedation, one after patient became conversational. One patient developed transient laryngospasm (0.25%, 95% CI 0-1.2%) unrelated to vomiting. There were nil aspiration events (0%, 95% CI 0-0.74%). CONCLUSIONS: Seventy per cent of patients undergoing ED procedural sedation are not fasted. No patient had a clinically evident adverse outcome. Transient respiratory events occur but can be managed with basic airway interventions making propofol a safe alternative for emergency physicians to provide emergent procedural sedation.
|
Authors | Anthony Bell, Greg Treston, Charley McNabb, Kathy Monypenny, Robert Cardwell |
Journal | Emergency medicine Australasia : EMA
(Emerg Med Australas)
Vol. 19
Issue 5
Pg. 405-10
(Oct 2007)
ISSN: 1742-6731 [Print] Australia |
PMID | 17919212
(Publication Type: Journal Article)
|
Chemical References |
- Hypnotics and Sedatives
- Propofol
|
Topics |
- Adolescent
- Adult
- Adverse Drug Reaction Reporting Systems
- Aged
- Conscious Sedation
(adverse effects, methods)
- Emergency Service, Hospital
- Female
- Health Status Indicators
- Humans
- Hypnotics and Sedatives
(adverse effects, therapeutic use)
- Male
- Middle Aged
- Propofol
(adverse effects, therapeutic use)
- Prospective Studies
- Respiratory Function Tests
- Respiratory Tract Diseases
(chemically induced)
- Risk Factors
- Time Factors
- Vomiting
(chemically induced)
|