Abstract | BACKGROUND: To evaluate the clinical utility of pancreatic scintigraphy with 99mTc-interleukin-2 to identify Type 1 diabetic patients with pancreatic inflammation at diagnosis. METHODS:
99mTc-interleukin-2 scintigraphy was performed on 42 newly diagnosed Type 1 diabetic patients, before and after 1 year of treatment with nicotinamide (25 or 50 mg/kg/day) in addition to intensive insulin therapy. Metabolic status was monitored every 3 months for 1 year. Sixteen normal subjects were studied as control. RESULTS: Significant pancreatic accumulation of 99mTc-interleukin-2 was found in 31% of the patients at the time of diagnosis. Patients positive or negative for pancreatic accumulation of interleukin-2 scintigraphy did not show any difference in metabolic or immunologic parameters at diagnosis. Positive patients, however, showed higher C-peptide values at 3 months and lower insulin requirement at 1 year, compared to negative patients ( insulin requirement (IR): 0.33+/-0.11 vs 0.67+/-0.24 IU/kg/day, positive vs negative patients; p=0.0001); patients positive to IL2 scintigraphy treated with nicotinamide at 25 mg/kg were the only group showing a significant reduction in IR 1 year after diagnosis (IRt0: 0.53+/-0.30 vs IRt12: 0.28+/-0.07 IU/kg/day; p=0.013). After 1 year, all the positive patients showed a significant decrease in pancreatic uptake of 99mTc-interleukin-2 (P/B: 7.87+/-2.28 at diagnosis vs 5.00+/-1.23 after 1 year; p<0.0001 paired t-test). CONCLUSION:
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Authors | M Chianelli, M G Parisella, N Visalli, S J Mather, C D'Alessandria, P Pozzilli, A Signore, IMDIAB study group |
Journal | Diabetes/metabolism research and reviews
(Diabetes Metab Res Rev)
Vol. 24
Issue 2
Pg. 115-22
(Feb 2008)
ISSN: 1520-7552 [Print] England |
PMID | 17918277
(Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Copyright | Copyright (c) 2007 John Wiley & Sons, Ltd. |
Chemical References |
- Interleukin-2
- Organotechnetium Compounds
- technetium Tc 99m interleukin 2
- Niacinamide
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Topics |
- Adolescent
- Adult
- Child
- Diabetes Mellitus, Type 1
(diagnostic imaging, drug therapy)
- Follow-Up Studies
- Humans
- Interleukin-2
- Niacinamide
(therapeutic use)
- Organotechnetium Compounds
- Pancreas
(diagnostic imaging)
- Radionuclide Imaging
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