Abstract | OBJECTIVES: Over the last two decades, increasing interest has been focused on the association between autoimmune polyneuropathies and anti-neuronal autoantibodies in immune-mediated polyneuropathy. The possible appearance of these autoantibodies in systemic diseases that are not limited to the nervous system has not been fully addressed yet. METHODS: RESULTS: CONCLUSION: Anti-GM1 and anti- sulfatide antibodies are frequently found in patients with small vessel ANCA-associated vasculitis and other multi-organ immune-mediated diseases. Upon detection of these antibodies, accurate neurologic examination should be carried out due to the significant association that can be found between these serologic abnormalities and the involvement of the peripheral nervous system as also detected by electrophysiologic studies. This study supports the unexpected possibility that anti-neuronal reactivity may be a direct trigger of neurologic injury in these systemic disorders.
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Authors | M Alpa, B Ferrero, R Cavallo, A Perna, C Naretto, M Gennaro, D Di Simone, L Bellizia, M Mansouri, D Rossi, V Modena, O Giachino, L M Sena, D Roccatello |
Journal | Clinical and experimental rheumatology
(Clin Exp Rheumatol)
2007 Jul-Aug
Vol. 25
Issue 4
Pg. 556-62
ISSN: 0392-856X [Print] Italy |
PMID | 17888211
(Publication Type: Journal Article)
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Chemical References |
- Autoantibodies
- Immunoglobulin G
- Immunoglobulin M
- Sulfoglycosphingolipids
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Topics |
- Adult
- Autoantibodies
(blood)
- Cryoglobulinemia
(immunology)
- Female
- Gangliosidosis, GM1
(immunology)
- Humans
- Immunoglobulin G
(blood)
- Immunoglobulin M
(blood)
- Lupus Erythematosus, Systemic
(immunology)
- Male
- Middle Aged
- Sjogren's Syndrome
(immunology)
- Sulfoglycosphingolipids
(immunology)
- Vasculitis
(immunology)
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