Abstract | CONTEXT: OBJECTIVES: We conducted a gene expression profiling of benign and malignant tumors to identify a gene signature that would allow us to discriminate benign from malignant pheochromocytomas and to gain a better understanding of tumorigenic pathways associated with malignancy. DESIGN: A total of 36 patients with pheochromocytoma was studied retrospectively. There were 18 (nine benign and nine malignant) tumors used for gene expression profiling on pangenomic oligonucleotide microarrays. RESULTS: CONCLUSION: The gene expression profiling of benign and malignant pheochromocytomas clearly identified a set of genes that could be used as a prognostic multi-marker and revealed that the expression of several genes encoding neuroendocrine proteins was reduced in malignant compared with benign tumors.
|
Authors | Erwan Thouënnon, Abdel G Elkahloun, Johann Guillemot, Anne-Paule Gimenez-Roqueplo, Jérôme Bertherat, Alice Pierre, Hafida Ghzili, Luca Grumolato, Mihaela Muresan, Marc Klein, Hervé Lefebvre, L'Houcine Ouafik, Hubert Vaudry, Pierre-François Plouin, Laurent Yon, Youssef Anouar |
Journal | The Journal of clinical endocrinology and metabolism
(J Clin Endocrinol Metab)
Vol. 92
Issue 12
Pg. 4865-72
(Dec 2007)
ISSN: 0021-972X [Print] United States |
PMID | 17878247
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Genetic Markers
- RNA, Neoplasm
|
Topics |
- Adolescent
- Adrenal Gland Neoplasms
(genetics, pathology)
- Adult
- Aged
- Aged, 80 and over
- Child
- Child, Preschool
- Female
- Genetic Markers
- Humans
- Infant
- Male
- Middle Aged
- Oligonucleotide Array Sequence Analysis
- Pheochromocytoma
(genetics, pathology)
- RNA, Neoplasm
(biosynthesis, genetics)
- Reproducibility of Results
- Reverse Transcriptase Polymerase Chain Reaction
|