Abstract | BACKGROUND:
Asthma can frequently be induced or exacerbated by respiratory viral infections. Oxidative stress might also play an essential role in the pathogenesis of allergic airway diseases, indicating that antioxidant therapy may have a potential effect in controlling allergic airway diseases. Recent studies showed that 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside ( AICAR) has the potential ability to modulate NADPH oxidase activity, indicating the antioxidant activity of AICAR. This study investigated the inhibitory effects of AICAR as an anti-inflammatory modulator on allergic airway inflammation in murine animal models. METHODS: RESULTS: CONCLUSION: These findings suggest that AICAR may be a novel immunomodulator with promising beneficial effects for the treatment of respiratory viral infection in airway allergic diseases.
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Authors | T-B Kim, S Y Kim, K-A Moon, C-S Park, M K Jang, E S Yun, Y S Cho, H-B Moon, K-Y Lee |
Journal | Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
(Clin Exp Allergy)
Vol. 37
Issue 11
Pg. 1709-19
(Nov 2007)
ISSN: 0954-7894 [Print] England |
PMID | 17877757
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cytokines
- Immunoglobulins
- Immunologic Factors
- Lymphotoxin-alpha
- NF-kappa B
- Reactive Oxygen Species
- Ribonucleotides
- Aminoimidazole Carboxamide
- Ovalbumin
- AICA ribonucleotide
- Poly I-C
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Topics |
- Aminoimidazole Carboxamide
(analogs & derivatives, pharmacology, therapeutic use)
- Animals
- Asthma
(chemically induced, drug therapy, physiopathology, prevention & control)
- Bronchoalveolar Lavage Fluid
(chemistry, cytology, immunology)
- Cell Count
- Cell Line
- Cell Line, Tumor
- Cytokines
(metabolism)
- Dendritic Cells
(drug effects, metabolism, pathology)
- Eosinophils
(drug effects, metabolism, pathology)
- Female
- HeLa Cells
- Humans
- Immunoglobulins
(blood)
- Immunologic Factors
(pharmacology, therapeutic use)
- Lung
(drug effects, metabolism, pathology)
- Lymphotoxin-alpha
(metabolism)
- Macrophages, Alveolar
(drug effects, metabolism, pathology)
- Mice
- Mice, Inbred BALB C
- NF-kappa B
(metabolism)
- Ovalbumin
(immunology)
- Poly I-C
(toxicity)
- Reactive Oxygen Species
(metabolism)
- Respiratory Hypersensitivity
(chemically induced, physiopathology, prevention & control)
- Ribonucleotides
(pharmacology, therapeutic use)
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