Abstract | PURPOSE: MATERIALS AND METHODS: RESULTS: Of the men 2,583 reported 1 or more episodes of nocturia and finished 12 or more months of the trial. Mean nocturia was similar in all groups at baseline. Mean nocturia was reduced at 1 year by 0.35, 0.40, 0.54 and 0.58 in the placebo, finasteride, doxazosin and combination groups, respectively. Reductions with doxazosin and combination therapy were statistically greater than with placebo (p <0.05). At 4 years nocturia was also significantly reduced in patients treated with doxazosin and combination therapy (p <0.05 vs placebo). In men older than 70 years (495) all drugs significantly reduced nocturia at 1 year ( finasteride 0.29, doxazosin 0.46 and combination 0.42) compared to placebo (0.11, p <0.05). CONCLUSIONS:
Doxazosin and combination therapy reduced nocturia more than placebo, but the net benefit of active drug compared to placebo was often modest with a net difference of less than 0.20 fewer nightly nocturia episodes at 1 and 4 years. Findings in men 70 years old or older were similar, with an even smaller effect observed for finasteride.
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Authors | Theodore M Johnson 2nd, Pamela K Burrows, John W Kusek, Leroy M Nyberg, J Lisa Tenover, Herbert Lepor, Claus G Roehrborn, Medical Therapy of Prostatic Symptoms Research Group |
Journal | The Journal of urology
(J Urol)
Vol. 178
Issue 5
Pg. 2045-50; discussion 2050-1
(Nov 2007)
ISSN: 0022-5347 [Print] United States |
PMID | 17869295
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Adrenergic alpha-Antagonists
- Enzyme Inhibitors
- Finasteride
- Doxazosin
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Topics |
- Adrenergic alpha-Antagonists
(administration & dosage, therapeutic use)
- Dose-Response Relationship, Drug
- Double-Blind Method
- Doxazosin
(administration & dosage, therapeutic use)
- Drug Therapy, Combination
- Enzyme Inhibitors
(administration & dosage, therapeutic use)
- Finasteride
(administration & dosage, therapeutic use)
- Follow-Up Studies
- Humans
- Male
- Middle Aged
- Nocturia
(drug therapy, etiology, physiopathology)
- Pilot Projects
- Prostatic Hyperplasia
(complications, drug therapy, physiopathology)
- Treatment Outcome
- Urodynamics
(drug effects)
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