[(11)C]-PIB imaging in patients with Parkinson's disease: preliminary results.

Abstract

[(11)C]-PIB positron emission tomography ([(11)C]-PIB PET) is a sensitive marker of amyloid in Alzheimer's disease (AD), but its specificity has not been fully evaluated. Vascular amyloid-beta deposition is common in Parkinson's disease (PD) and alpha-synuclein, the major component of the Lewy bodies in PD, forms amyloid fibrils. We investigated five apparently cognitively normal PD patients with [(11)C]-PIB PET. The results were compared to 16 patients with AD and six healthy controls from a previous study. [(11)C]-PIB retention was not significantly increased in our patients who all had early stage PD. Further studies of more advanced PD patients are warranted.

• Authors: A Johansson, I Savitcheva, A Forsberg, H Engler, B Långström, A Nordberg, H Askmark
• Journal: Parkinsonism & related disorders (Parkinsonism Relat Disord) Vol. 14 Issue 4 Pg. 345-7 ( 2008) ISSN: 1353-8020 [Print] England
• PMID: 17855149 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole
• Aniline Compounds
• Benzothiazoles
• Thiazoles

Topics

• Aged
• Aniline Compounds
• Benzothiazoles (metabolism)
• Brain Mapping
• Female
• Humans
• Image Processing, Computer-Assisted
• Male
• Middle Aged
• Parkinson Disease (diagnostic imaging)
• Positron-Emission Tomography (methods)
• Thiazoles