Abstract | BACKGROUND: PATIENTS AND METHODS: We conducted a retrospective study over a period of eight years (1994-2001). The patients were referred during this period and were followed until December 2003. PF and PV were included based on clinical, histological and immunopathological criteria. RESULTS: In our study there was no significant difference between PF group and PV group concerning; age, sex, duration of the disease, presence of disseminated lesions, treatment, healing time, remission, relapse, complications, death and follows up duration. The survival graph showed no difference between the two groups for the first two relapses. There was a tendency to significance concerning an additional treatment and relapses frequency in the PF group. CONCLUSIONS: Few studies in the literature were interested in the evolution of the two forms of pemphigus. They showed that the two populations share the same clinical course; nevertheless they revealed the frequency of partial remission, failed treatment, relapses, necessity of high dose of corticosteroids, and difficulties of discontinuing treatment in PF. Our study, suggests that PF and PV may share the same clinical course.
|
Authors | I Zaraa, M Mokni, M Hsairi, S Boubaker, M Sellami, M Zitouni, S Makni, A Ben Osman Dhahri |
Journal | International journal of dermatology
(Int J Dermatol)
Vol. 46
Issue 9
Pg. 923-6
(Sep 2007)
ISSN: 0011-9059 [Print] England |
PMID | 17822493
(Publication Type: Comparative Study, Journal Article)
|
Chemical References |
- Autoantibodies
- Desmoglein 1
- Desmoglein 3
- Immunosuppressive Agents
- Prednisone
|
Topics |
- Adult
- Aged
- Autoantibodies
(analysis)
- Desmoglein 1
(immunology)
- Desmoglein 3
(immunology)
- Female
- Fluorescent Antibody Technique, Direct
- Humans
- Immunoblotting
- Immunosuppressive Agents
(administration & dosage)
- Kaplan-Meier Estimate
- Male
- Middle Aged
- Pemphigus
(classification, diagnosis, drug therapy, epidemiology)
- Prednisone
(administration & dosage)
- Prognosis
- Recurrence
- Retrospective Studies
|