Effect of gomisin A in the prevention of acute hepatic failure induction.

Abstract

Nearly all rats develop massive hepatic cell necrosis and die upon intravenous administration of heat-killed Propionibacterium acnes followed by a small amount of Gram-negative lipopolysaccharide 7 days later. However, when such an experimental liver disorder is induced in rats raised for 4 or more weeks on food containing 0.06% of gomisin A extracted and purified from Schizandra chinensis, the survival rate rises, histological changes of the liver improve remarkably, and splenocyte reactivity to phytohemagglutinin and pokeweed mitogen as well as splenocyte interleukin 1 productivity are retained. These results suggested the possibility that the development of acute hepatic failure may be prevented with the oral administration of gomisin A.

• Authors: Y Mizoguchi, N Kawada, Y Ichikawa, H Tsutsui
• Journal: Planta medica (Planta Med) Vol. 57 Issue 4 Pg. 320-4 (Aug 1991) ISSN: 0032-0943 [Print] Germany
• PMID: 1775571 (Publication Type: Journal Article)

Chemical References

• Cyclooctanes
• Dioxoles
• Interleukin-1
• Lignans
• Polycyclic Compounds
• schizandrol B
• Transaminases

Topics

• Animals
• Cyclooctanes
• Diet
• Dioxoles
• Interleukin-1 (biosynthesis)
• Lignans
• Liver Diseases (prevention & control)
• Male
• Polycyclic Compounds (therapeutic use)
• Propionibacterium acnes
• Rats
• Rats, Inbred Strains
• Spleen (cytology, drug effects, metabolism)
• Transaminases (blood)