Collagenous colitis and eosinophilic gastritis in a 4-year old girl: a case report and review of the literature.

Abstract

UNLABELLED:

Collagenous colitis (CC), a form of microscopic colitis, is characterized by a thick subepithelial collagen layer in the colon in the presence of chronic nonbloody watery diarrhoea and macroscopically normal-appearing colonic mucosa. Typically affecting elderly adults, CC is rare in children with only 12 cases previously reported in the literature. We report the case of a 4-year-old girl with CC associated with eosinophilic gastritis, which was clinically responsive to treatment with ketotifen, a benzocycloheptathiophene derivative, and H(1) class of antihistamine that stabilizes mast cells and potentially impairs eosinophil migration to target organs. We review the published cases of paediatric-onset CC and summarize the links between eosinophils and CC in the clinical and basic science literature.

CONCLUSION:

CC is a rare cause of chronic diarrhoea in children and may relate to mast cell and eosinophil activity.

• Authors: Eric I Benchimol, Richard Kirsch, Sandra Viero, Anne M Griffiths
• Journal: Acta paediatrica (Oslo, Norway : 1992) (Acta Paediatr) Vol. 96 Issue 9 Pg. 1365-7 (Sep 2007) ISSN: 0803-5253 [Print] Norway
• PMID: 17718794 (Publication Type: Case Reports, Journal Article, Review)

Topics

• Colitis, Collagenous (epidemiology, pathology)
• Duodenoscopy
• Eosinophils (metabolism)
• Esophagoscopy
• Female
• Gastritis (epidemiology, metabolism, pathology)
• Humans
• Infant
• Mast Cells (metabolism)
• Pyloric Antrum (metabolism, pathology)