Abstract | OBJECTIVES: METHODS: RESULTS:
Catalpol attenuated ischemia-induced apoptotic death via preventing the decrease in the level of Bcl-2 protein and the activities of SOD and GSH-PX, inhibiting the reduction of mitochondrial membrane potential and suppressing activation of caspase-3. DISCUSSION: The results suggest that the catalpol has the potential to prevent ischemic-induced apoptosis.
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Authors | Zhuo Wang, Li-Jia An, Yan-Long Duan, Ya-Chen Li, Bo Jiang |
Journal | Neurological research
(Neurol Res)
Vol. 30
Issue 1
Pg. 106-12
(Feb 2008)
ISSN: 0161-6412 [Print] England |
PMID | 17716390
(Publication Type: Journal Article)
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Chemical References |
- Drugs, Chinese Herbal
- Glucosides
- Iridoid Glucosides
- Iridoids
- Proto-Oncogene Proteins c-bcl-2
- Reactive Oxygen Species
- catalpol
- Glutathione Peroxidase
- Superoxide Dismutase
- Caspase 3
- Glucose
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Topics |
- Animals
- Apoptosis
(drug effects)
- Caspase 3
(metabolism)
- Cell Count
- Dose-Response Relationship, Drug
- Drugs, Chinese Herbal
(therapeutic use)
- Glucose
(deficiency)
- Glucosides
(therapeutic use)
- Glutathione Peroxidase
(metabolism)
- Hypoxia
(prevention & control)
- Iridoid Glucosides
- Iridoids
(therapeutic use)
- Membrane Potential, Mitochondrial
(drug effects)
- PC12 Cells
- Proto-Oncogene Proteins c-bcl-2
(metabolism)
- Rats
- Reactive Oxygen Species
(metabolism)
- Superoxide Dismutase
(metabolism)
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