Cystinyl aminopeptidase activity is decreased in renal cell carcinomas.
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| Abstract |
The involvement of peptidases in carcinogenetic processes of several tumor types has been researched in recent years. Although kidney is one of the major tissues known to express cystinyl-aminopeptidase (CAP), little is known about its role in renal neoplasia. This study analyzes fluorimetrically membrane-bound and soluble CAP activity in the three main renal cancers: clear cell (CCRCC), papillary (PRCC), and chromophobe (ChRCC) renal cell carcinomas. Overall, a marked decrease of membrane-bound CAP activity in all the three renal cell carcinomas was detected when compared with their respective surrounding non-tumor tissues. So, the tumor vs. non-tumor CAP ratios (units of peptidase per mg of protein) was as follows: 926+/-111 vs. 3778+/-276 for CCRCCs, 737+/-181 vs. 4351+/-950 for PRCCs, and 592+/-118 vs. 4905+/-935 for ChRCCs. In contrast, the soluble fraction of this enzyme displayed minor and non-significant changes when comparing tumor and non-tumor CAP activities in the whole series. After stratification by stage and grade, CCRCCs displayed significant differences: pT3 category had significantly higher levels of membrane-bound activity than pT1, and high grade cases (G3-4) had higher soluble CAP activity than low grade ones (G1-2). These data may open additional possibilities in the study of renal cell carcinoma with regard to the prognosis of patients.
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| Authors | Gorka Larrinaga, José I López, Luis Casis, Lorena Blanco, Javier Gil, Ekaitz Agirregoitia, Adolfo Varona |
| Journal | Regulatory peptides (Regul Pept) Vol. 144 Issue 1-3 Pg. 56-61 (Dec 04 2007) ISSN: 0167-0115 [Print] Netherlands |
| PMID | 17692401 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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