Abstract |
Although some isoprenoids, such as taxans and geranylgeraniol (GGOH), have been reported to have strong anticancer activities, the effect of plaunotol, the isoprenoid extracted from the leaves of Plau-noi, on cancer has not yet been evaluated. Here, we aimed to investigate the effect of plaunotol on gastric cancer cell lines. Three gastric cancer cell lines, namely MKN-45, MKN-74 and AZ-521 were used. Plaunotol was tested at 10, 20, 30 and 40 micromol/L. Plaunotol dose-dependently inhibited the growth of all gastric cancer cells, dependent on the induction of apoptosis. Caspases-8, -9 and -3, were found to be activated in the apoptotic cells. The expression of Bax protein was increased, but Bcl-2 and Bcl-xL protein expressions were not significantly affected. Plaunotol should be a promising new antitumor agent, and since it is already available for clinical use in Japan, its anticancer properties should be confirmed in clinical trials.
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Authors | Jun Yamada, Kazushige Kawai, Nelson H Tsuno, Joji Kitayama, Takeshi Tsuchiya, Satomi Yoneyama, Masahiro Asakage, Yurai Okaji, Koki Takahashi, Hirokazu Nagawa |
Journal | Planta medica
(Planta Med)
Vol. 73
Issue 10
Pg. 1068-73
(Aug 2007)
ISSN: 0032-0943 [Print] Germany |
PMID | 17691055
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antineoplastic Agents, Phytogenic
- Diterpenes
- Fatty Alcohols
- Plant Extracts
- Caspases
- plaunotol
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Topics |
- Antineoplastic Agents, Phytogenic
(administration & dosage, pharmacology, therapeutic use)
- Apoptosis
(drug effects)
- Caspases
(metabolism)
- Cell Line, Tumor
(drug effects)
- Croton
- Diterpenes
- Dose-Response Relationship, Drug
- Fatty Alcohols
(administration & dosage, pharmacology, therapeutic use)
- Flow Cytometry
- Humans
- In Situ Nick-End Labeling
- Phytotherapy
- Plant Extracts
(administration & dosage, pharmacology, therapeutic use)
- Stomach Neoplasms
(pathology)
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