Abstract | BACKGROUND: Primary liver cancer is a common malignancy with a dismal prognosis. New primary prevention strategies are needed to reduce mortality from this disease. We examined the effects of supplementation with four different combinations of vitamins and minerals on primary liver cancer mortality among 29450 initially healthy adults from Linxian, China. METHODS: RESULTS: A total of 151 liver cancer deaths occurred during the analysis period. No statistically significant differences in liver cancer mortality were found comparing the presence and absence of any of the four intervention factors. However, both factor A and factor B reduced liver cancer mortality in individuals younger than 55 years at randomization (HR = 0.59, 95% CI = 0.34 to 1.00, and HR = 0.54, 95% CI = 0.31 to 0.93, respectively) but not in older individuals (HR = 1.06, 95% CI = 0.71 to 1.59, and HR = 1.12, 95% CI = 0.75 to 1.68, respectively). Factor C reduced liver cancer death, albeit with only borderline statistical significance in males (HR = 0.70, 95% CI = 0.47 to 1.02) but not in females (HR = 1.30, 95% CI = 0.72 to 2.37). Cumulative risks of liver cancer death were 6.0 per 1000 in the placebo arm, 5.4 per 1000 in the arms with two factors, and 2.4 per 1000 in the arm with all four factors. CONCLUSION: None of the factors tested reduced overall liver cancer mortality. However, three factors reduced liver cancer mortality in certain subgroups.
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Authors | Chen-Xu Qu, Farin Kamangar, Jin-Hu Fan, Binbing Yu, Xiu-Di Sun, Philip R Taylor, Bingshu E Chen, Christian C Abnet, You-Lin Qiao, Steven D Mark, Sanford M Dawsey |
Journal | Journal of the National Cancer Institute
(J Natl Cancer Inst)
Vol. 99
Issue 16
Pg. 1240-7
(Aug 15 2007)
ISSN: 1460-2105 [Electronic] United States |
PMID | 17686823
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Research Support, N.I.H., Intramural)
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Chemical References |
- Antibodies, Neoplasm
- Minerals
- Vitamins
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Topics |
- Adult
- Antibodies, Neoplasm
(blood)
- Chemoprevention
- China
- Double-Blind Method
- Drug Therapy, Combination
- Female
- Humans
- Incidence
- Liver Neoplasms
(mortality, prevention & control)
- Male
- Middle Aged
- Minerals
(therapeutic use)
- Vitamins
(therapeutic use)
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