Abstract | OBJECTIVE: METHODS AND RESULTS: Among 5633 participants who were not using lipid-lowering medications, greater ACR was associated with greater triglyceride concentration and lesser high density lipoprotein cholesterol concentration (women only), but not with low density lipoprotein ( LDL) cholesterol calculated using conventional methods. In contrast, unadjusted mean small LDL particle concentrations measured by NMR were 770, 827 and 935 nmol/L for women (p<0.001) and 996, 1030 and 1040 nmol/L for men (p=0.037) among participants with normal, high normal and elevated ACR. Adjusting for age, race/ethnicity, diabetes, impaired fasting glucose, hypertension, smoking, medications, body mass index and serum creatinine, each two-fold greater ACR was associated with an increase in small LDL particle concentration of 27 nmol/L for women (p<0.001) and 14 nmol/L for men (p=0.008). Greater ACR was also associated with greater intermediate density lipoprotein particle concentration and smaller mean LDL particle size. CONCLUSIONS: Mild elevations of urine ACR are associated with atherogenic lipoprotein abnormalities that are not directly observed with a standard lipid panel.
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Authors | Ian H de Boer, Brad C Astor, Holly Kramer, Walter Palmas, Kyle Rudser, Stephen L Seliger, Michael G Shlipak, David S Siscovick, Michael Y Tsai, Bryan Kestenbaum |
Journal | Atherosclerosis
(Atherosclerosis)
Vol. 197
Issue 1
Pg. 407-14
(Mar 2008)
ISSN: 1879-1484 [Electronic] Ireland |
PMID | 17681346
(Publication Type: Journal Article, Multicenter Study, Research Support, N.I.H., Extramural)
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Chemical References |
- Cholesterol, HDL
- Cholesterol, VLDL
- Lipoproteins, LDL
- Creatinine
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Topics |
- Aged
- Aged, 80 and over
- Albuminuria
(ethnology, urine)
- Asian
(statistics & numerical data)
- Atherosclerosis
(ethnology, urine)
- Black People
(statistics & numerical data)
- Cholesterol, HDL
(blood, chemistry)
- Cholesterol, VLDL
(blood, chemistry)
- Creatinine
(blood)
- Cross-Sectional Studies
- Ethnicity
(statistics & numerical data)
- Female
- Hispanic or Latino
(statistics & numerical data)
- Humans
- Kidney
(metabolism)
- Lipoproteins, LDL
(blood, chemistry)
- Male
- Middle Aged
- Nuclear Magnetic Resonance, Biomolecular
- Particle Size
- Prevalence
- Risk Factors
- United States
(epidemiology)
- White People
(statistics & numerical data)
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