Abstract | OBJECTIVES: METHODS: The PyNpase levels in tumor tissue, normal tissue adjacent to the tumor, and normal tissue apart from the tumor were measured in 102 patients. Additionally, the PyNpase levels were measured in rat and mouse urinary bladders treated with BBN. RESULT: The PyNpase levels of tumor tissue significantly correlated to the tumor grade and growth pattern (papillary/non-papillary), while stage, multiplicity, and tumor shape (peduncle/sessile) were not independent factors. The low-risk tumor of primary, single, G1-Ta showed significantly low levels of PyNpase. The PyNpase levels in the tumor tissue were significantly higher than those in the normal tissue. The PyNpase levels in the adjacent normal tissue were significantly higher than those in the distant normal tissue. The PyNpase levels in rat bladder tissue were significantly higher in the BBN-treatment groups than in those in the control group, only during the early carcinogenic stage. The PyNpase levels in mouse bladder tissue were significantly higher in BBN-treatment groups than in those in the control group during the whole experiment period. CONCLUSION: Our results indicated that not only tumor tissue but also normal tissue adjacent to the tumor had a potential of angiogenesis for tumor development, and transurethral resection of the bladder tumor with a wide normal margin seems to be a reasonable strategy for decreasing the risk of recurrence.
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Authors | Kiyohide Fujimoto, Yoshiaki Matsumura, Yoshihiro Tani, Seiichiro Ozono, Yoshihiko Hirao, Eigoro Okajima |
Journal | International journal of urology : official journal of the Japanese Urological Association
(Int J Urol)
Vol. 14
Issue 8
Pg. 754-9
(Aug 2007)
ISSN: 0919-8172 [Print] Australia |
PMID | 17681069
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Carcinogens
- Butylhydroxybutylnitrosamine
- Pentosyltransferases
- Pyrimidine Phosphorylases
- Thymidine Phosphorylase
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Animals
- Butylhydroxybutylnitrosamine
- Carcinogens
- Carcinoma, Papillary
(epidemiology, metabolism, pathology)
- Female
- Humans
- Male
- Mice
- Mice, Inbred C3H
- Middle Aged
- Neoplasm Invasiveness
- Neoplasm Recurrence, Local
(metabolism)
- Pentosyltransferases
(metabolism)
- Pyrimidine Phosphorylases
- Rats
- Rats, Inbred F344
- Risk Factors
- Species Specificity
- Thymidine Phosphorylase
(metabolism)
- Urinary Bladder
(enzymology, pathology)
- Urinary Bladder Neoplasms
(epidemiology, metabolism, pathology)
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