Abstract | BACKGROUND: The potential for toxicity from systemic absorption of topical miconazole in infants is a concern. OBJECTIVE: To assess the relative safety of 0.25% miconazole based on the amount absorbed through the skin of infants with diaper dermatitis after multiple applications. METHODS: RESULTS: In the 0.25% treatment group, blood concentrations of miconazole were nondetectable (< 1 ng/mL) in 83% (15/18) and minimal (3.0 to 3.8 ng/mL) in 17% (3/18). Samples were missing for one patient. For the 5 infants in the 2% treatment group, miconazole concentration was nondetectable in 20% (1/5) and less than 7.4 ng/mL in 4 infants. No adverse events were noted. CONCLUSIONS:
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Authors | Lawrence F Eichenfield, Melissa L Bogen |
Journal | Journal of drugs in dermatology : JDD
(J Drugs Dermatol)
Vol. 6
Issue 5
Pg. 522-6
(May 2007)
ISSN: 1545-9616 [Print] United States |
PMID | 17679187
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antifungal Agents
- Ointments
- Miconazole
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Topics |
- Antifungal Agents
(administration & dosage, adverse effects, pharmacokinetics)
- Diaper Rash
(drug therapy, etiology, metabolism)
- Female
- Gastrointestinal Diseases
(complications)
- Humans
- Infant
- Male
- Miconazole
(administration & dosage, adverse effects, pharmacokinetics)
- Ointments
- Severity of Illness Index
- Skin Absorption
- Treatment Outcome
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