Enhanced healing of mitomycin C-treated wounds in rats using inbred adipose tissue-derived stromal cells within an atelocollagen matrix.
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| Abstract |
The aim of this study was to evaluate the potential accelerating effects of an adipose tissue-derived stromal cells (ATSC)-containing atelocollagen matrix with silicone membrane (ACMS) for repairing mitomycin C-treated healing-impaired wounds. Mitomycin C was applied to full-thickness skin incisions in this study to create a healing-impaired wound model in rat. After thoroughly washing out the mitomycin C from the wound, ACMS alone or ATSC-containing ACMS was applied to the wounds. Histological sections of the wounds were then prepared at indicated time periods after the treatments. These results indicated significantly advanced granulation tissue and capillary formations in the healing-impaired wounds treated with ATSC-containing ACMS compared with those treated with ACMS alone. Thus, this study suggested that transplantation of inbred ATSC-containing ACMS is effective for repairing healing-impaired wounds.
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| Authors | Masaki Nambu, Masayuki Ishihara, Shingo Nakamura, Hiroshi Mizuno, Satoshi Yanagibayashi, Yasuhiro Kanatani, Hidemi Hattori, Bonpei Takase, Takamitsu Ishizuka, Satoko Kishimoto, Yoshiko Amano, Naoto Yamamoto, Ryuichi Azuma, Tomoharu Kiyosawa |
| Journal | Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society (Wound Repair Regen) 2007 Jul-Aug Vol. 15 Issue 4 Pg. 505-10 ISSN: 1067-1927 [Print] United States |
| PMID | 17650094 (Publication Type: Comparative Study, Journal Article) |
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