Abstract | BACKGROUND: METHODS: In an in vivo model of TEA in awake rats with acute pancreatitis, we evaluated blood gas analysis, arterial blood pressure, and exhaled nitric oxide. This was followed by in vitro studies of receptor-dependent and receptor-independent pulmonary vasoconstriction using an isolated perfused lung model. Pulmonary myeloperoxidase activity, indicating leukocyte sequestration into the lungs and wet/dry ratio evaluating pulmonary edema, were also measured. RESULTS: CONCLUSIONS: Our study demonstrated that TEA improves pancreatitis-associated impairment of pulmonary vasoreactivity and gas exchange.
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Authors | Stefan Lauer, Hendrik Freise, Lars G Fischer, Kai Singbartl, Hugo V Aken, Markus M Lerch, Andreas W Sielenkämper |
Journal | Anesthesia and analgesia
(Anesth Analg)
Vol. 105
Issue 2
Pg. 453-9
(Aug 2007)
ISSN: 1526-7598 [Electronic] United States |
PMID | 17646505
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Analgesia, Epidural
(methods)
- Animals
- Blood Gas Analysis
(methods)
- Blood Pressure
(physiology)
- Lung Diseases
(physiopathology, prevention & control)
- Male
- Pancreatitis
(physiopathology, prevention & control)
- Pulmonary Circulation
(physiology)
- Rats
- Rats, Sprague-Dawley
- Thorax
(physiology)
- Vasoconstriction
(physiology)
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