Micronized diosmin (Detralex) for vein-related trophic ulcers: European experience.

Abstract

The paper presents a meta-analysis of 5 large European studies (N - 723) on the micronized diosmin administration to patients with venous trophic ulcers (CEAP class VI). With the use of evidence-based approach, it was shown that micronized diosmin has a statistically significant clinical effect on middle-sized trophic ulcers (5 - 10 cm(2)) that persisted for 6 - 12 months. The study concludes that polyvalent venotonics are an appropriate and valuable addition to complex therapy of complicated chronic venous insufficiency.

• Authors: V S Savel'ev, A V Pokrovskiĭ, S V Sapelkin, V Iu Bogachev, L I Bogdanets, I A Zolotukhin
• Journal: Angiologiia i sosudistaia khirurgiia = Angiology and vascular surgery (Angiol Sosud Khir) Vol. 12 Issue 3 Pg. 53-60 ( 2006) ISSN: 1027-6661 [Print] Russia (Federation)
• PMID: 17641615 (Publication Type: Journal Article, Meta-Analysis)

Chemical References

• Diosmin

Topics

• Adult
• Aged
• Aged, 80 and over
• Atherosclerosis (drug therapy, physiopathology)
• Diosmin (therapeutic use)
• Europe
• Female
• Humans
• Leg Ulcer (drug therapy, pathology)
• Lower Extremity (blood supply)
• Male
• Middle Aged
• Varicose Ulcer (drug therapy, pathology)