Abstract |
Quetiapine ( Seroquel) is the only atypical antipsychotic approved in the US for use as monotherapy in both bipolar mania and depression, offering potential compliance advantages. Monotherapy with oral quetiapine 300 mg/day is effective in the treatment of patients with bipolar I or II depression. Rapid and sustained improvements in depressive and anxiety symptoms are seen with quetiapine, as well as improvements in health-related quality of life. Quetiapine is generally well tolerated in bipolar depression and is not associated with an increased risk of treatment-emergent mania. Thus, despite the current lack of data from active comparator trials, quetiapine monotherapy should be considered a first-line option for the acute treatment of bipolar depression.
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Authors | Gillian M Keating, Dean M Robinson |
Journal | CNS drugs
(CNS Drugs)
Vol. 21
Issue 8
Pg. 695-7
( 2007)
ISSN: 1172-7047 [Print] New Zealand |
PMID | 17630822
(Publication Type: Journal Article, Review)
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Chemical References |
- Antipsychotic Agents
- Dibenzothiazepines
- Quetiapine Fumarate
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Topics |
- Antipsychotic Agents
(therapeutic use)
- Bipolar Disorder
(drug therapy, psychology)
- Dibenzothiazepines
(therapeutic use)
- Humans
- Quality of Life
- Quetiapine Fumarate
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