Abstract | OBJECTIVES: METHODS AND RESULTS: In 205 subjects with normal or mildly elevated blood pressure, we assessed sodium intake and left ventricular structure and function by echocardiography. Intronic +1,675 G/A polymorphism of the AT2R gene was investigated. A-allele carriers had a greater LVM (P = 0.049) than G-allele carriers. Independent of diet, septal wall thickness was higher in A-allele carriers (P = 0.001). Fractional fibre shortening was greater in A-allele carriers (P = 0.034), and the velocity of circumferential fibre shortening tended to be greater in A-allele carriers (P = 0.057). When the two groups were stratified according to their salt intake, only G-allele carriers displayed a modulating effect of salt intake on LVM. Covariance analysis revealed that there was a trend towards a modulating effect of salt intake on LVM, even after taking blood pressure into account (P = 0.054). CONCLUSION: Our data clearly support the notion that LVM is influenced by AT2R polymorphisms. Furthermore, G-allele carriers in particular appear to be susceptible to a modifying effect of increased salt intake on LVM.
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Authors | Christian Ott, Stephanie I Titze, Thomas K Schwarz, Reinhold Kreutz, Karl F Hilgers, Bernhard M W Schmidt, Markus P Schlaich, Roland E Schmieder |
Journal | Journal of hypertension
(J Hypertens)
Vol. 25
Issue 8
Pg. 1627-32
(Aug 2007)
ISSN: 0263-6352 [Print] Netherlands |
PMID | 17620959
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Receptors, Angiotensin
- Sodium, Dietary
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Topics |
- Alleles
- Blood Pressure
(genetics)
- Genetic Carrier Screening
- Humans
- Hypertrophy, Left Ventricular
(genetics, pathology)
- Receptors, Angiotensin
(genetics)
- Sodium, Dietary
(administration & dosage)
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