Abstract | BACKGROUND AND PURPOSE: METHODS: We prospectively analyzed numbers of newly appeared dotHSs in 12 patients with prior SVD (8 males, 4 females; mean 67.6 +/- 10.7 years old) readmitted with recurring SVD between October 2001 and March 2003. Numbers of appeared dotHSs per year were counted on T2*-w MRI scans after SVD recurrence and compared to previous MRIs. Seventy-one outpatients (35 males, 36 females; mean 64.3 +/- 9.6 years old) with histories of intracerebral hemorrhages (ICH) that came to the hospital during the study period served as controls. The hazard ratio (HR) for recurrence was estimated from a multivariate logistic regression model, using the number of appeared dotHSs (per year) and other risk factors. RESULTS: Multivariate analyses revealed that an elevated rate of recurrence was found in patients with substantial numbers of appeared dotHSs (>or=5/year) (HR, 7.34; P= 0.0008). We also analyzed factors associated with the numbers of appeared dotHSs. A number of appeared dotHSs (>or=5/year) was significantly and independently associated with the initial number of dotHSs (>or=10) on T2*-w MRIs following the first SVD (HR, 18.6; P= 0.0001). CONCLUSIONS: Though a small sample size limited the power of our analyses, our findings suggest that a number of newly appeared dotHSs may be associated with SVD recurrence.
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Authors | Toshio Imaizumi, Toshimi Honma, Yoshifumi Horita, Masahiko Chiba, Maiko Kawamura, Kei Miyata, Ikuhide Kohama, Jun Niwa |
Journal | Journal of neuroimaging : official journal of the American Society of Neuroimaging
(J Neuroimaging)
Vol. 17
Issue 3
Pg. 204-10
(Jul 2007)
ISSN: 1051-2284 [Print] United States |
PMID | 17608905
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Aged
- Cerebral Hemorrhage
(pathology)
- Female
- Hemosiderin
(analysis)
- Humans
- Logistic Models
- Magnetic Resonance Imaging
(methods)
- Male
- Middle Aged
- Prospective Studies
- Recurrence
- Risk Factors
- Statistics, Nonparametric
- Stroke
(pathology)
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