Neuroprotective and antiamnesic effects of Semax during experimental ischemic infarction of the cerebral cortex.

Abstract

Semax had a pronounced neuroprotective and antiamnesic effect during focal photoinduced ischemia of the prefrontal cortex. Intranasal administration of Semax for 6 days decreased the volume of cortical infarction and improved retention and performance of conditioned passive avoidance response.

• Authors: G A Romanova, D N Silachev, F M Shakova, Yu N Kvashennikova, I V Viktorov, S I Shram, N F Myasoedov
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 142 Issue 6 Pg. 663-6 (Dec 2006) ISSN: 0007-4888 [Print] United States
• PMID: 17603664 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Neuroprotective Agents
• Peptide Fragments
• ACTH (4-7), Pro-Gly-Pro-
• Adrenocorticotropic Hormone

Topics

• Administration, Intranasal
• Adrenocorticotropic Hormone (administration & dosage, analogs & derivatives, pharmacology)
• Amnesia (drug therapy)
• Animals
• Animals, Outbred Strains
• Brain Infarction (etiology, pathology, prevention & control)
• Cerebral Cortex (drug effects, pathology)
• Ischemic Attack, Transient (complications)
• Male
• Neuroprotective Agents (administration & dosage, pharmacology)
• Peptide Fragments (administration & dosage, pharmacology)
• Rats
• Treatment Outcome