Paraneoplastic limbic encephalitis caused by ovarian teratoma with autoantibodies to glutamate receptor.

Abstract

We report a rare case of paraneoplastic limbic encephalitis with autoantibodies to glutamate receptor (GluR) in the cerebrospinal fluid (CSF). The 35-year-old woman with consciousness disturbance was diagnosed initially as non-herpetic encephalitis. Her signs and symptoms improved with acyclovir and steroid pulse therapy. However, after the treatment, an ovarian tumor was discovered, and we detected autoantibodies to GluR in the CSF. A possible association between the ovarian teratoma and GluR is suggested.

• Authors: Sadahisa Okamoto, Teruyuki Hirano, Yukitoshi Takahashi, Taro Yamashita, Eiichiro Uyama, Makoto Uchino
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 46 Issue 13 Pg. 1019-22 ( 2007) ISSN: 1349-7235 [Electronic] Japan
• PMID: 17603244 (Publication Type: Case Reports, Journal Article)

Chemical References

• Autoantibodies
• Receptors, Glutamate

Topics

• Adult
• Autoantibodies (analysis, immunology)
• Biopsy, Needle
• Female
• Follow-Up Studies
• Humans
• Immunohistochemistry
• Japan
• Limbic Encephalitis (etiology, immunology)
• Ovarian Neoplasms (complications, pathology, surgery)
• Ovariectomy (methods)
• Rare Diseases
• Receptors, Glutamate (immunology)
• Risk Assessment
• Teratoma (complications, pathology, surgery)
• Treatment Outcome