Abstract | OBJECTIVE: METHOD: Five pregnant women with syphilis who were allergic to penicillin were given azithromycin, 1 g daily orally or intravenously, in different hospitals. The duration of the therapy ranged from 1 day to 10 days. A second course of therapy was provided at 28 weeks gestation. The babies were given a physical examination and blood test for serum rapid plasma reagin test (RPR), treponema pallidum hemagglutination test (TPHA), and fluorescent treponemal antibody adsorption test (FTA-ABS-19-sIgM) within three months after birth. RESULTS: Five infants born to these mothers developed skin rashes. Four of the infants had hepatomegaly and one showed osteochondritis. The tests RPR, TPHA, and FTA-ABS-19-sIgM were positive. The RPR titers varied from 1:64 to 1:256 and the babies were diagnosed with congenital syphilis. They were successfully treated with penicillin. CONCLUSIONS:
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Authors | Pingyu Zhou, Yihong Qian, Jinhua Xu, Zhiying Gu, Kanghuang Liao |
Journal | Sexually transmitted diseases
(Sex Transm Dis)
Vol. 34
Issue 7
Pg. 472-4
(Jul 2007)
ISSN: 0148-5717 [Print] United States |
PMID | 17589329
(Publication Type: Journal Article)
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Chemical References |
- Anti-Bacterial Agents
- Azithromycin
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Topics |
- Administration, Oral
- Adult
- Anti-Bacterial Agents
(administration & dosage, therapeutic use)
- Azithromycin
(administration & dosage, therapeutic use)
- China
(epidemiology)
- Drug Administration Schedule
- Female
- Humans
- Infant, Newborn
- Infectious Disease Transmission, Vertical
(prevention & control)
- Infusions, Intravenous
- Male
- Pregnancy
- Pregnancy Complications, Infectious
(blood, epidemiology, etiology, prevention & control)
- Prenatal Care
- Syphilis
(blood, epidemiology, etiology, prevention & control, transmission)
- Syphilis Serodiagnosis
- Syphilis, Congenital
(blood, epidemiology, etiology, prevention & control)
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