Cellular mechanisms of brain hypoglycemia.

Abstract

Data on intracellular processes induced by a low glucose level in nerve tissue are presented. The involvement of glutamate and adenosine receptors, mitochondria, reactive oxygen species (ROS), and calcium ions in the development of hypoglycemia-induced damage of neurons is considered. Hypoglycemia-induced calcium overload of neuronal mitochondria is suggested to be responsible for the increased ROS production by mitochondria.

• Authors: N K Isaev, E V Stel'mashuk, D B Zorov
• Journal: Biochemistry. Biokhimiia (Biochemistry (Mosc)) Vol. 72 Issue 5 Pg. 471-8 (May 2007) ISSN: 0006-2979 [Print] United States
• PMID: 17573700 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Glutamates
• Reactive Oxygen Species
• Calcium

Topics

• Animals
• Brain (metabolism, pathology)
• Calcium (metabolism)
• Glutamates (metabolism)
• Humans
• Hypoglycemia (metabolism, physiopathology)
• Mitochondria (metabolism)
• Models, Biological
• Neurons (metabolism, pathology)
• Reactive Oxygen Species (metabolism)