Abstract | BACKGROUND: METHODS: A retrospective study of 28 consecutive patients with parathyroid carcinoma, 7 patients with atypical parathyroid adenoma, and 13 patients with parathyromatosis who were treated at the University of California at San Francisco Medical Center between 1966 and 2005 was performed. Patient demographics and clinical characteristics, indication for surgery, intraoperative findings, histopathologic characteristics, disease recurrence or persistence, site of invasion/ metastases, and survival were compared in the 3 groups. RESULTS:
Parathyroid carcinoma (19 of 28 patients) and atypical adenoma (4 of 7 patients) were significantly more common in men, whereas parathyromatosis was more common in women (10 of 13 patients) (P = .02). A palpable neck mass and hoarseness were almost exclusively present in patients with parathyroid carcinoma. Prior to the first parathyroid surgery, patients with parathyroid carcinoma were found to have higher blood calcium levels (>/=14 mg/dL in 16 of 26 patients [62%]), whereas only 1 of 6 patients with atypical adenoma (17%) and no patients with parathyromatosis were found to have profound hypercalcemia (P < .01). Intraoperatively, patients with parathyroid carcinoma and atypical adenoma presented with single lesions, whereas patients with parathyromatosis had multiple small lesions. Histopathologic findings were well defined in parathyroid carcinoma, but some findings overlapped in the 3 tumors studied. CONCLUSIONS:
|
Authors | Gustavo G Fernandez-Ranvier, Elham Khanafshar, Kristin Jensen, Rasa Zarnegar, James Lee, Electron Kebebew, Quan-Yang Duh, Orlo H Clark |
Journal | Cancer
(Cancer)
Vol. 110
Issue 2
Pg. 255-64
(Jul 15 2007)
ISSN: 0008-543X [Print] United States |
PMID | 17559137
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Topics |
- Adenoma
(pathology, surgery)
- Adult
- Aged
- Carcinoma
(pathology, surgery)
- Female
- Humans
- Hyperparathyroidism
(pathology, surgery)
- Male
- Middle Aged
- Neoplasm Metastasis
- Parathyroid Neoplasms
(pathology, surgery)
- Recurrence
- Retrospective Studies
- Survival Analysis
|