Abstract | BACKGROUND: Because the efficacy of carboplatin and cisplatin in the treatment of advanced non-small-cell lung cancer (NSCLC) has not been proven to be equivalent, an individual patient data meta-analysis comparing the two treatments was performed. METHODS: Randomized trials comparing carboplatin to cisplatin in first-line treatment of advanced NSCLC were identified and their electronic databases obtained. A general variance-based method was used to estimate the summary hazard ratios (HRs), odds ratios ( ORs), and their 95% confidence intervals (CIs) for mortality, objective response, and toxicity. Cochran's chi-square test (Q test) was used to test for heterogeneity among trials, and the I2 index, which expresses the proportion of variability of the results due to heterogeneity, was calculated. A random-effects model that takes into account interstudy variation was also applied. All statistical tests were two-sided. RESULTS: Nine trials that included a total of 2968 patients were analyzed; overall median follow-up was 1021 days. The objective response rate was higher for patients treated with cisplatin than for patients treated with carboplatin (30% versus 24%, respectively; OR = 1.37; 95% CI = 1.16 to 1.61; P<.001). Carboplatin treatment was associated with a non-statistically significant increase in the hazard of mortality relative to treatment with cisplatin (HR = 1.07; 95% CI = 0.99 to 1.15; P = .100). In patients with nonsquamous tumors and those treated with third-generation chemotherapy, carboplatin-based chemotherapy was associated with a statistically significant increase in mortality (HR = 1.12; 95% CI = 1.01 to 1.23 and HR = 1.11; 95% CI = 1.01 to 1.21, respectively). Cisplatin-based chemotherapy was associated with more severe nausea and vomiting and nephrotoxicity; severe thrombocytopenia was more frequent during carboplatin-based chemotherapy. CONCLUSIONS: Our individual patient data meta-analysis suggests that cisplatin-based chemotherapy is slightly superior to carboplatin-based chemotherapy in terms of response rate and, in certain subgroups, in prolonging survival without being associated with an increase in severe toxic effects. Therefore, cisplatin-based third-generation regimens should remain the standard reference for the treatment of selected patients with advanced-stage NSCLC and of those with earlier-stage disease.
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Authors | Andrea Ardizzoni, Luca Boni, Marcello Tiseo, Frank V Fossella, Joan H Schiller, Marianne Paesmans, Davorin Radosavljevic, Adriano Paccagnella, Petr Zatloukal, Paola Mazzanti, Donald Bisset, Rafael Rosell, CISCA (CISplatin versus CArboplatin) Meta-analysis Group |
Journal | Journal of the National Cancer Institute
(J Natl Cancer Inst)
Vol. 99
Issue 11
Pg. 847-57
(Jun 06 2007)
ISSN: 1460-2105 [Electronic] United States |
PMID | 17551145
(Publication Type: Comparative Study, Journal Article, Meta-Analysis)
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Chemical References |
- Antineoplastic Agents
- Carboplatin
- Cisplatin
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Topics |
- Antineoplastic Agents
(therapeutic use)
- Carboplatin
(therapeutic use)
- Carcinoma, Non-Small-Cell Lung
(drug therapy)
- Cisplatin
(therapeutic use)
- Humans
- Lung Neoplasms
(drug therapy)
- Randomized Controlled Trials as Topic
- Survival Rate
- Treatment Outcome
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