Abstract | OBJECTIVE: METHODS: Basal insulin therapy was changed to one daily injection of IG in 30 pediatric patients with T1D (14 boys and 16 girls; age 4.5-18.3 yr, median 14.2 yr; diabetes duration 0.5-15.6 yr, median 4.6 yr) having elevated fasting glucose or recurrent hypoglycemia despite treatment with multiple injection therapy (basal insulin: two to four injections of neutral protamine Hagedorn (NPH) and/or zinc lente insulin). Ambulatory CGMS was applied before and 6-8 wk after treatment change. Frequency of hypoglycemic and hyperglycemic episodes, glucose area under the curve (AUC), and time below 60 mg/dL and above 180 mg/dL, respectively, were calculated from CGMS data during the day (8:00-22:00 hours) and at night (22:00-8:00 hours). RESULTS: Nocturnal hypoglycemia was detected by CGMS in 20 patients before and in 12 patients after the change to IG (p = .039), whereas both, the number of nocturnal and diurnal hypoglycemic episodes, decreased not significantly from 41 to 36 (p = .758) and 48 to 28 (p = .055), respectively. AUC and time below 60 mg/dL as well as hemoglobin A1c (HbA1c) were not significantly different before and after the change to IG. CONCLUSION: Under treatment with IG, asymptomatic hypoglycemia was reduced without increase of HbA1c.
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Authors | Dorothee Deiss, Olga Kordonouri, Reinhard Hartmann, Werner Hopfenmüller, Kerstin Lüpke, Thomas Danne |
Journal | Pediatric diabetes
(Pediatr Diabetes)
Vol. 8
Issue 3
Pg. 157-62
(Jun 2007)
ISSN: 1399-543X [Print] Denmark |
PMID | 17550426
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Blood Glucose
- Glycated Hemoglobin A
- Hypoglycemic Agents
- Insulin
- Insulin, Long-Acting
- Insulin Glargine
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Topics |
- Adolescent
- Blood Glucose
(drug effects, metabolism)
- Child
- Diabetes Mellitus, Type 1
(blood, drug therapy)
- Drug Administration Schedule
- Female
- Glycated Hemoglobin
(metabolism)
- Humans
- Hypoglycemia
(epidemiology, prevention & control)
- Hypoglycemic Agents
(administration & dosage, therapeutic use)
- Injections, Subcutaneous
- Insulin
(administration & dosage, analogs & derivatives, therapeutic use)
- Insulin Glargine
- Insulin, Long-Acting
- Male
- Monitoring, Ambulatory
(methods)
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