Abstract | OBJECTIVES: METHODS: Thirty-five Sprague-Dawley rats were unilaterally myringotomized. The rats were divided into four groups randomly: group 1 received no treatment, group 2 received intraperitoneally administered saline and group 3 received intraperitoneally administered CAPE. The tympanic membranes were examined by otomicroscopy on the 15th day after treatment. The membranes were then harvested and evaluated histologically by light microscopy. RESULTS: The tympanic membranes from group 1 showed extensive myringosclerosis; those from group 2 showed a similar occurrence of myringosclerosis. However, group 3 had a reduced occurrence of myringosclerosis by otomicroscopic evaluation. Under light microscopic examination, the lamina propria of the pars tensa was found to be thicker and more sclerotic in groups 1 and 2 when compared with group 3. CONCLUSIONS: Systemic treatment with CAPE was found to be effective in the prevention of sclerotic lesions in myringotomized rat tympanic membranes.
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Authors | Jae-Jun Song, Seong Keun Kwon, Chang Gun Cho, Seok-Won Park |
Journal | International journal of pediatric otorhinolaryngology
(Int J Pediatr Otorhinolaryngol)
Vol. 71
Issue 8
Pg. 1287-91
(Aug 2007)
ISSN: 0165-5876 [Print] Ireland |
PMID | 17544518
(Publication Type: Evaluation Study, Journal Article)
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Chemical References |
- Caffeic Acids
- NF-kappa B
- caffeic acid phenethyl ester
- Phenylethyl Alcohol
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Topics |
- Animals
- Caffeic Acids
(pharmacology, therapeutic use)
- Male
- NF-kappa B
(antagonists & inhibitors)
- Phenylethyl Alcohol
(analogs & derivatives)
- Random Allocation
- Rats
- Rats, Sprague-Dawley
- Sclerosis
(chemically induced, prevention & control)
- Tympanic Membrane
(drug effects, pathology)
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