Possible novel receptor for PGD2 on human bronchial epithelial cells.

Abstract

Prostaglandin D(2) (PGD(2)), a major prostanoid produced by activated mast cells, has long been implicated in allergic diseases. Recent studies have shown that PGD(2) exerts its effects through two different G-protein-coupled receptors (GPCRs), the D-prostanoid receptor (DP) and the chemoattractant receptor-homologous molecule expressed on T helper type-2 cells (CRTH2), expressed in various human tissues. The PGD(2)/CRTH2 system mediates the chemotaxis of eosinophils, basophils, and Th2 cells, which are involved in the induction of allergic inflammation. We have reported that normal human bronchial epithelial cells (NHBE) and epithelial cell lines (NCI-H(292)) expressed CRTH2, and PGD(2) induces production of IL-8 and GM-CSF. This review discusses the role of CRTH2/DP on epithelial cells and mentions a possible novel receptor for PGD(2).

• Authors: Takahito Chiba, Akira Kanda, Shigeharu Ueki, Wataru Ito, Kazutoshi Yamaguchi, Yumiko Kamada, Masahide Takeda, Tomomi Tanigai, Hajime Oyamada, Hiroyuki Kayaba, Junichi Chihara
• Journal: International archives of allergy and immunology (Int Arch Allergy Immunol) Vol. 143 Suppl 1 Pg. 23-7 ( 2007) ISSN: 1423-0097 [Electronic] Switzerland
• PMID: 17541272 (Publication Type: Journal Article, Review)

Chemical References

• Interleukin-8
• RNA, Messenger
• Receptors, Immunologic
• Receptors, Prostaglandin
• Granulocyte-Macrophage Colony-Stimulating Factor
• Prostaglandin D2
• prostaglandin D2 receptor

Topics

• Asthma (physiopathology)
• Bronchi (cytology)
• Bronchitis (etiology, physiopathology)
• Cell Line (drug effects, metabolism)
• Chemotaxis (drug effects, physiology)
• Epithelial Cells (chemistry, drug effects, physiology)
• Granulocyte-Macrophage Colony-Stimulating Factor (biosynthesis)
• Humans
• Interleukin-8 (biosynthesis)
• MAP Kinase Signaling System (drug effects)
• Organ Specificity
• Prostaglandin D2 (pharmacology, physiology)
• RNA, Messenger (biosynthesis)
• Receptors, Immunologic (agonists, classification, isolation & purification, physiology)
• Receptors, Prostaglandin (agonists, classification, isolation & purification, physiology)
• Respiratory Hypersensitivity (physiopathology)
• Th2 Cells (immunology)