Assessment of antianginal efficacy of long-acting sustained release isosorbide dinitrate in comparison with short-acting isosorbide dinitrate.

Abstract

A quadruple blind randomized cross-over study evaluated the therapeutic efficacy of twice a day long acting sustained release isosorbide dinitrate (SRISDN) in comparison with 4 times daily of the short acting isosorbide dinitrate in 18 patients with stable angina pectoris (NYHA class II-III) with a positive exercise treadmill test. The antianginal effect of sustained release isosorbide dinitrate (SRISDN) (exercise duration 472.61 +/- 112.49 sec and anginal episodes per week (1.33 +/- 1.18) was not significantly different (p less than 0.05) when compared to conventional isosorbide dinitrate (exercise duration 468.33 +/- 135.28 sec and anginal episodes per week 1.55 +/- 104). Twice a day long acting sustained release isosorbide dinitrate is as effective as four times a day conventional short acting isosorbide dinitrate. Such a regimen is likely to lead to a better patient compliance and ease of antianginal therapy.

• Authors: Y V Rao, K S Reddy, H S Wasir
• Journal: Indian heart journal (Indian Heart J) 1991 Mar-Apr Vol. 43 Issue 2 Pg. 97-100 ISSN: 0019-4832 [Print] India
• PMID: 1752623 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Delayed-Action Preparations
• Isosorbide Dinitrate

Topics

• Adult
• Angina Pectoris (drug therapy, physiopathology)
• Coronary Vessels (drug effects, physiopathology)
• Delayed-Action Preparations
• Drug Administration Schedule
• Exercise Test
• Humans
• Isosorbide Dinitrate (administration & dosage)
• Middle Aged
• Time Factors