Abstract | CONTEXT: OBJECTIVE: The aim of this study was to determine the effects of a moderate weight reduction program on intracellular lipid and glucose metabolism in muscle and liver. PARTICIPANTS: Data for 13 nondiabetic obese subjects were evaluated. INTERVENTION: Subjects were put on a 3-month mildly hypocaloric diet therapy (approximately 35 kcal/kg of ideal body weight). MAIN OUTCOME MEASURES: Intrahepatic lipid (IHL) and intramyocellular lipid were measured by using (1)H magnetic resonance spectroscopy. Peripheral insulin sensitivity and splanchnic glucose uptake were evaluated by euglycemic-hyperinsulinemic clamp with oral glucose load. RESULTS:
Diet therapy for 3 months resulted in 6% reduction in body weight (from 99.9 +/- 7.3 to 93.8 +/- 6.6 kg, P < 0.0001). This change was accompanied by reduction of plasma glucose and insulin excursions during 75-g oral glucose tolerance tests, decrease in diastolic blood pressure, glycated hemoglobin, serum low-density lipoprotein cholesterol, and triglyceride. These changes were also accompanied by a decrease in IHL (from 12.9 to 8.2%, P < 0.01) and increase in splanchnic glucose uptake (from 13.5 to 35.0%, P < 0.03). On the other hand, the diet program did not affect intramyocellular lipid or glucose infusion rate during euglycemic hyperinsulinemic clamp. CONCLUSIONS: Our results suggest that moderate weight reduction in obese subjects decreased IHL and augmented splanchnic glucose uptake. This mechanism is at least in part involved in improvement of glucose metabolism by moderate weight reduction in obese subjects.
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Authors | Fumihiko Sato, Yoshifumi Tamura, Hirotaka Watada, Naoki Kumashiro, Yasuhiro Igarashi, Hiroshi Uchino, Tadayuki Maehara, Shinsuke Kyogoku, Satoshi Sunayama, Hiroyuki Sato, Takahisa Hirose, Yasushi Tanaka, Ryuzo Kawamori |
Journal | The Journal of clinical endocrinology and metabolism
(J Clin Endocrinol Metab)
Vol. 92
Issue 8
Pg. 3326-9
(Aug 2007)
ISSN: 0021-972X [Print] United States |
PMID | 17519317
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adipose Tissue
(metabolism)
- Body Mass Index
- Diet, Reducing
- Glucose
(metabolism)
- Glucose Clamp Technique
- Humans
- Insulin Resistance
(physiology)
- Lipid Metabolism
(physiology)
- Liver
(metabolism)
- Magnetic Resonance Spectroscopy
- Muscle Cells
(metabolism)
- Muscle, Skeletal
(metabolism)
- Obesity
(diet therapy, metabolism)
- Triglycerides
(metabolism)
- Weight Loss
(physiology)
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