Anthraquinones, Cdc25B phosphatase inhibitors, isolated from the roots of Polygonum multiflorum Thunb.

Abstract

Three anthraquinones, Cdc25B phosphatase inhibitors, were isolated from the methanolic extract of the roots of Polygonum multiflorum Thunb. (Polygonaceae). Anthraquinones, physcion (1), emodin (2), and questin (3), inhibited the enzymatic activity of Cdc25B phosphatase with IC(50) values of 62.5, 30, and 34 microg mL(-1), respectively. Emodin (2) and questin (3) strongly inhibited the growth of human colon cancer cells, SW620 with GI(50) values of 6.1 and 0.9 microg mL(-1), respectively. Commercially available anthraquinones, chrysophanol (4), and rhein (5) also inhibited Cdc25B phosphatase with IC(50) values of 10.7 and 22.1 microg mL(-1), respectively.

• Authors: Sung-Gyu Choi, Jiin Kim, Nack-Do Sung, Kwang-Hee Son, Hyae-Gyeong Cheon, Kwang-Rok Kim, Byoung-Mog Kwon
• Journal: Natural product research (Nat Prod Res) Vol. 21 Issue 6 Pg. 487-93 (May 20 2007) ISSN: 1478-6419 [Print] England
• PMID: 17497420 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cell Cycle Proteins
• Enzyme Inhibitors
• questin
• CDC25B protein, human
• cdc25 Phosphatases
• physcione
• Emodin

Topics

• Cell Cycle Proteins (antagonists & inhibitors)
• Cell Line, Tumor
• Colonic Neoplasms
• Emodin (analogs & derivatives, chemistry, isolation & purification, pharmacology)
• Enzyme Inhibitors (isolation & purification, pharmacology)
• Humans
• Molecular Structure
• Plant Roots (chemistry)
• Polygonum (chemistry)
• cdc25 Phosphatases (antagonists & inhibitors)