Abstract | BACKGROUND & AIMS: The loss of parietal cells from the gastric mucosa (oxyntic atrophy) is a critical step in the pathogenesis of chronic gastritis and gastric adenocarcinoma. Parietal cells are known to secrete epidermal growth factor receptor (EGFR) ligands, which are critical regulators of differentiation in the gastric mucosa. Although all of the actions of EGFR ligands are mediated through a common EGFR protein, individual ligands may produce different physiologic responses. Previous investigations have suggested that a deficit in EGFR signaling in waved-2 mice accelerates the emergence of metaplasia after induction of acute oxyntic atrophy. We sought to determine whether specific EGFR ligands regulate the metaplastic response to oxyntic atrophy. METHODS: RESULTS: CONCLUSIONS: The absence of AR promoted the rapid emergence of SPEM in response to oxyntic atrophy.
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Authors | Ki Taek Nam, Andrea Varro, Robert J Coffey, James R Goldenring |
Journal | Gastroenterology
(Gastroenterology)
Vol. 132
Issue 5
Pg. 1804-19
(May 2007)
ISSN: 0016-5085 [Print] United States |
PMID | 17484876
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Amphiregulin
- Areg protein, mouse
- Azetidines
- EGF Family of Proteins
- Gastrins
- Glycoproteins
- Intercellular Signaling Peptides and Proteins
- Peptides
- Piperazines
- Transforming Growth Factor alpha
- Trefoil Factor-2
- spasmolytic polypeptide
- DMP 777
- Somatostatin
- Intrinsic Factor
- ErbB Receptors
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Topics |
- Amphiregulin
- Animals
- Atrophy
(chemically induced, pathology)
- Azetidines
- EGF Family of Proteins
- ErbB Receptors
(genetics, physiology)
- Gastric Mucosa
(metabolism, pathology)
- Gastrins
(genetics, metabolism)
- Gene Expression Regulation
- Glycoproteins
(genetics, metabolism)
- Intercellular Signaling Peptides and Proteins
(genetics, metabolism)
- Intrinsic Factor
(genetics, metabolism)
- Male
- Metaplasia
(chemically induced, pathology)
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Parietal Cells, Gastric
(metabolism, pathology)
- Peptides
(genetics, metabolism, physiology)
- Piperazines
- S Phase
- Somatostatin
(genetics, metabolism)
- Transforming Growth Factor alpha
(genetics, physiology)
- Trefoil Factor-2
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