Abstract | BACKGROUND AND AIMS: METHODS:
Antibodies against a mannan epitope of Saccharomyces cerevisiae (gASCA), laminaribioside (ALCA), chitobioside (ACCA), mannobioside ( AMCA), outer membrane porins (Omp) and the atypical perinuclear antineutrophilic cytoplasmic antibody (pANCA) were tested in serum samples of 1225 IBD patients, 200 healthy controls and 113 patients with non-IBD gastrointestinal inflammation. Antibody responses were correlated with the type of disease and clinical characteristics. RESULTS: 76% of Crohn's disease patients had at least one of the tested antibodies. For differentiation between Crohn's disease and ulcerative colitis, the combination of gASCA and pANCA was most accurate. For differentiation between IBD, healthy controls and non-IBD gastrointestinal inflammation, the combination of gASCA, pANCA and ALCA had the best accuracy. Increasing amounts and levels of antibody responses against gASCA, ALCA, ACCA, AMCA and Omp were associated with more complicated disease behaviour (44.7% versus 53.6% versus 71.1% versus 82.0%, p < 0.001), and a higher frequency of Crohn's disease-related abdominal surgery (38.5% versus 48.8% versus 60.7% versus 75.4%, p < 0.001). CONCLUSIONS: Using this new panel of serological markers, the number and magnitude of immune responses to different microbial antigens were shown to be associated with the severity of the disease. With regard to the predictive role of serological markers, further prospective longitudinal studies are necessary.
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Authors | Marc Ferrante, Liesbet Henckaerts, Marie Joossens, Marie Pierik, Sofie Joossens, Nir Dotan, Gary L Norman, Rom T Altstock, Kristel Van Steen, Paul Rutgeerts, Gert Van Assche, Séverine Vermeire |
Journal | Gut
(Gut)
Vol. 56
Issue 10
Pg. 1394-403
(Oct 2007)
ISSN: 0017-5749 [Print] England |
PMID | 17456509
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies, Bacterial
- Antibodies, Fungal
- Antigens, Bacterial
- Biomarkers
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Topics |
- Adult
- Aged
- Antibodies, Bacterial
(blood)
- Antibodies, Fungal
(blood)
- Antigens, Bacterial
(immunology)
- Biomarkers
(blood)
- Colitis, Ulcerative
(diagnosis, microbiology, pathology)
- Crohn Disease
(diagnosis, microbiology, pathology)
- Diagnosis, Differential
- Epidemiologic Methods
- Humans
- Inflammatory Bowel Diseases
(diagnosis, microbiology, pathology)
- Middle Aged
- Saccharomyces cerevisiae
(immunology)
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