Composite lymphoma of the orbit treated with rituximab.

Abstract

We describe an unusual case of composite lymphoma (CL) in the orbit. The clinical history and biopsy specimen of an 82-year-old woman with a right orbital mass were evaluated. The orbital biopsy contained a dense lymphocytic infiltration and nodules of large lymphocyte that immunostained positive for CD20. Flow cytometric immunophenotyping showed two distinct populations of cells, confirming the diagnosis of a simultaneous follicular lymphoma (FL) and chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). The patient was treated with CD20 antibody (rituximab) and is in remission at 3 months follow-up.

• Authors: Shin J Kang, Ingo Schmack, Ted H Wojno, Hans E Grossniklaus
• Journal: Ophthalmic plastic and reconstructive surgery (Ophthalmic Plast Reconstr Surg) 2007 Mar-Apr Vol. 23 Issue 2 Pg. 143-4 ISSN: 0740-9303 [Print] United States
• PMID: 17413631 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Monoclonal
• Antibodies, Monoclonal, Murine-Derived
• Antigens, CD
• Antineoplastic Agents
• Rituximab

Topics

• Aged, 80 and over
• Antibodies, Monoclonal (therapeutic use)
• Antibodies, Monoclonal, Murine-Derived
• Antigens, CD (metabolism)
• Antineoplastic Agents (therapeutic use)
• Female
• Flow Cytometry
• Humans
• Immunophenotyping
• Leukemia, Lymphocytic, Chronic, B-Cell (drug therapy, metabolism, pathology)
• Leukemic Infiltration
• Lymphoma, Follicular (drug therapy, metabolism, pathology)
• Magnetic Resonance Imaging
• Neoplasms, Second Primary (drug therapy, metabolism, pathology)
• Orbital Neoplasms (drug therapy, metabolism, pathology)
• Rituximab