Abstract | OBJECTIVE: RESEARCH DESIGN AND METHODS: A post hoc analysis was conducted using 3-day bladder diary data from a 12-week, multicenter, prospective, open-label study of tolterodine ER (4 mg qd) in patients (aged > or = 18 years) with urinary frequency (> or = 8 micturitions/24 h) and urgency (strong and sudden desire to urinate) with or without urgency urinary incontinence (UUI). MAIN OUTCOME MEASURES: Changes in micturition frequency, urgency, and UUI episodes/24 h were evaluated for treatment Days 5, 6, and 7. The percentages of patients who achieved normal micturition frequency (< 8/day) and 50%, 70%, 90%, and 100% reductions in urgency and UUI episodes (i.e., responders) were determined at Days 5, 6, and 7. Week 12 data are presented as a referent for the magnitude of treatment efficacy during Week 1. RESULTS: This analysis included 698 patients. On Day 5, there were significant reductions in all three diary variables (all p < 0.0001), and improvements continued on Days 6 and 7. More than half of the patients reported > or = 50% reductions in urgency or UUI episodes on Day 5. Responder rates for all three symptoms increased through Week 12. CONCLUSIONS: Patients with OAB experienced significant reductions in OAB symptoms as early as Day 5 of treatment with tolterodine ER. These data extend the findings of a previous analysis, in which all 3 days of the bladder diary were pooled, that demonstrated improvements in micturition frequency, urgency episodes, and UUI episodes in patients with OAB after 1 week of treatment with tolterodine ER. Limitations are that efficacy was not assessed before Day 5, this was a post hoc analysis, and the study was not placebo-controlled.
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Authors | David O Sussman, Stephen R Kraus, Martin Carlsson, Zhonghong Guan |
Journal | Current medical research and opinion
(Curr Med Res Opin)
Vol. 23
Issue 4
Pg. 777-81
(Apr 2007)
ISSN: 1473-4877 [Electronic] England |
PMID | 17407634
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Chemical References |
- Benzhydryl Compounds
- Cresols
- Delayed-Action Preparations
- Muscarinic Antagonists
- Phenylpropanolamine
- Tolterodine Tartrate
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Benzhydryl Compounds
(administration & dosage, therapeutic use)
- Cresols
(administration & dosage, therapeutic use)
- Delayed-Action Preparations
(administration & dosage, therapeutic use)
- Female
- Humans
- Male
- Middle Aged
- Muscarinic Antagonists
(administration & dosage)
- Phenylpropanolamine
(administration & dosage, therapeutic use)
- Time Factors
- Tolterodine Tartrate
- Treatment Outcome
- Urinary Bladder, Overactive
(drug therapy)
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