Abstract | BACKGROUND: AIM: METHODS: Rats subjected to bile duct ligation (BDL) and to adrenergic denervation were fed a TC-enriched diet, in the absence or presence of daily administration of the phosphatidyl-inositol-3-kinase (PI3K) inhibitor wortmannin for 1 week. RESULTS: SUMMARY/CONCLUSIONS: TC administration prevents the damage of the biliary tree induced by the adrenergic denervation of the liver. These novel findings open novel perspectives in the understanding of the potential of bile acids especially in post- transplant liver disease.
|
Authors | Marco Marzioni, Yoshiyuki Ueno, Shannon Glaser, Heather Francis, Antonio Benedetti, Domenico Alvaro, Juliet Venter, Giammarco Fava, Gianfranco Alpini |
Journal | Liver international : official journal of the International Association for the Study of the Liver
(Liver Int)
Vol. 27
Issue 4
Pg. 558-68
(May 2007)
ISSN: 1478-3223 [Print] United States |
PMID | 17403196
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
|
Chemical References |
- Adrenergic Agents
- Androstadienes
- Phosphoinositide-3 Kinase Inhibitors
- Protective Agents
- Taurocholic Acid
- Proto-Oncogene Proteins c-akt
- Wortmannin
|
Topics |
- Adrenergic Agents
- Androstadienes
(administration & dosage, pharmacology)
- Animals
- Apoptosis
(drug effects)
- Biliary Tract
(drug effects)
- Cell Proliferation
(drug effects)
- Cholestasis
(drug therapy, etiology, pathology)
- Denervation
- Liver
(innervation)
- Phosphoinositide-3 Kinase Inhibitors
- Protective Agents
(administration & dosage)
- Proto-Oncogene Proteins c-akt
(metabolism)
- Rats
- Rats, Inbred Strains
- Taurocholic Acid
(administration & dosage, pharmacology)
- Wortmannin
|