Abstract | BACKGROUND: METHODS: RESULTS: CONCLUSIONS: The CETP inhibitor torcetrapib was associated with a substantial increase in HDL cholesterol and decrease in LDL cholesterol. It was also associated with an increase in blood pressure, and there was no significant decrease in the progression of coronary atherosclerosis. The lack of efficacy may be related to the mechanism of action of this drug class or to molecule-specific adverse effects. (ClinicalTrials.gov number, NCT00134173 [ClinicalTrials.gov].).
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Authors | Steven E Nissen, Jean-Claude Tardif, Stephen J Nicholls, James H Revkin, Charles L Shear, William T Duggan, Witold Ruzyllo, William B Bachinsky, Gabriel P Lasala, Gregory P Lasala, E Murat Tuzcu, ILLUSTRATE Investigators |
Journal | The New England journal of medicine
(N Engl J Med)
Vol. 356
Issue 13
Pg. 1304-16
(Mar 29 2007)
ISSN: 1533-4406 [Electronic] United States |
PMID | 17387129
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | Copyright 2007 Massachusetts Medical Society. |
Chemical References |
- Anticholesteremic Agents
- Cholesterol Ester Transfer Proteins
- Cholesterol, HDL
- Cholesterol, LDL
- Heptanoic Acids
- Pyrroles
- Quinolines
- torcetrapib
- Atorvastatin
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Topics |
- Adult
- Aged
- Anticholesteremic Agents
(adverse effects, therapeutic use)
- Atorvastatin
- Blood Pressure
(drug effects)
- Cardiovascular Diseases
(chemically induced)
- Cholesterol Ester Transfer Proteins
(adverse effects, antagonists & inhibitors)
- Cholesterol, HDL
(blood, metabolism)
- Cholesterol, LDL
(blood)
- Coronary Artery Disease
(diagnostic imaging, drug therapy, pathology)
- Disease Progression
- Double-Blind Method
- Drug Therapy, Combination
- Female
- Heptanoic Acids
(therapeutic use)
- Humans
- Male
- Middle Aged
- Prospective Studies
- Pyrroles
(therapeutic use)
- Quinolines
(adverse effects, therapeutic use)
- Ultrasonography, Interventional
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