Abstract | OBJECTIVES: METHODS: Between May 1999 and March 2006, 30 patients with idiopathic pulmonary fibrosis were referred to the Swallowing Center at the University of California San Francisco. Each patient underwent a structured symptom assessment, esophageal manometry, and 24-hour dual sensor ambulatory pH monitoring. RESULTS: Twenty (67%) patients had abnormal esophageal reflux. Typical reflux symptoms, although more common in those with reflux, were not reliable as a screening test (sensitivity 65%, specificity 71%). Sixty-five percent of patients with abnormal reflux had a hypotensive lower esophageal sphincter. Abnormal esophageal peristalsis was more common among those with reflux (50% vs 10%; P = .03). In 9 (30%) patients, acid refluxed into the proximal esophagus for over 1% of the study time. CONCLUSIONS: A majority of patients with idiopathic pulmonary fibrosis have pathologic reflux. Symptoms do not distinguish between those with and without reflux. In these patients, reflux is associated with a hypotensive lower esophageal sphincter and abnormal esophageal peristalsis, and often extends into the proximal esophagus.
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Authors | Matthew P Sweet, Marco G Patti, Lorriana E Leard, Jeffrey A Golden, Steven R Hays, Charles Hoopes, Pierre R Theodore |
Journal | The Journal of thoracic and cardiovascular surgery
(J Thorac Cardiovasc Surg)
Vol. 133
Issue 4
Pg. 1078-84
(Apr 2007)
ISSN: 1097-685X [Electronic] United States |
PMID | 17382656
(Publication Type: Journal Article)
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Topics |
- Comorbidity
- Female
- Gastroesophageal Reflux
(diagnosis, epidemiology)
- Humans
- Lung Transplantation
- Male
- Manometry
- Mass Screening
- Middle Aged
- Prevalence
- Pulmonary Fibrosis
(epidemiology, surgery)
- Retrospective Studies
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