Abstract | AIM: MATERIAL AND METHODS: RESULTS: RANKL levels were low in health and gingivitis groups, but increased in all three forms of periodontitis. OPG levels were higher in health than all three periodontitis, or gingivitis groups. There were no differences in RANKL and OPG levels between chronic and generalized aggressive periodontitis groups, whereas these were lower in the immunosuppressed chronic periodontitis group. The RANKL/OPG ratio was significantly elevated in all three periodontitis forms, compared with health or gingivitis, and positively correlated to probing pocket depth and clinical attachment level. CONCLUSION: GCF RANKL and OPG levels were oppositely regulated in periodontitis, but not gingivitis, resulting in an enhanced RANKL/OPG ratio. This ratio was similar in all three periodontitis groups and may therefore predict disease occurrence.
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Authors | Nagihan Bostanci, Tunc Ilgenli, Gülnur Emingil, Beral Afacan, Buket Han, Hüseyin Töz, Gül Atilla, Francis J Hughes, Georgios N Belibasakis |
Journal | Journal of clinical periodontology
(J Clin Periodontol)
Vol. 34
Issue 5
Pg. 370-6
(May 2007)
ISSN: 0303-6979 [Print] United States |
PMID | 17355365
(Publication Type: Journal Article)
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Chemical References |
- Osteoprotegerin
- RANK Ligand
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Topics |
- Adolescent
- Adult
- Alveolar Bone Loss
(metabolism)
- Case-Control Studies
- Female
- Gingival Crevicular Fluid
(chemistry)
- Gingivitis
(metabolism)
- Humans
- Immunosuppression Therapy
- Male
- Middle Aged
- Osteoprotegerin
(analysis, metabolism)
- Periodontitis
(metabolism)
- RANK Ligand
(analysis, metabolism)
- Statistics, Nonparametric
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