Abstract | BACKGROUND: METHODS: RESULTS: There were no significant between-group differences in hormone concentration and delta sleep at baseline. Relative to controls, women with PTSD had decreased ACTH and delta sleep responses to metyrapone. Decline in delta sleep was associated with the magnitude of increase in ACTH across groups. CONCLUSIONS: Similar to our previous findings in men, the ACTH and sleep electroencephalogram response to metyrapone is attenuated in women with PTSD. These results are consistent with a model of downregulation of CRF receptors in an environment of chronically increased CRF activity or with enhanced negative feedback regulation in PTSD.
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Authors | Christian Otte, Maryann Lenoci, Thomas Metzler, Rachel Yehuda, Charles R Marmar, Thomas C Neylan |
Journal | Biological psychiatry
(Biol Psychiatry)
Vol. 61
Issue 8
Pg. 952-6
(Apr 15 2007)
ISSN: 0006-3223 [Print] United States |
PMID | 17336940
(Publication Type: Clinical Trial, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Enzyme Inhibitors
- Adrenocorticotropic Hormone
- Cortodoxone
- Hydrocortisone
- Metyrapone
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Topics |
- Adrenocorticotropic Hormone
(blood)
- Adult
- Analysis of Variance
- Cortodoxone
(blood)
- Enzyme Inhibitors
(administration & dosage)
- Female
- Humans
- Hydrocortisone
(blood)
- Hypothalamo-Hypophyseal System
(drug effects)
- Metyrapone
(administration & dosage)
- Middle Aged
- Pituitary-Adrenal System
(drug effects)
- Polysomnography
- Sleep
(drug effects)
- Stress Disorders, Post-Traumatic
(blood, drug therapy, physiopathology)
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