Plasmodium yoelii: influence of antimalarial treatment on acquisition of immunity in BALB/c and DBA/2 mice.
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| Abstract |
The effect of antimalarial drugs on immune responses to the malaria infection is evaluated in vivo using two experimental self-cured rodent models. BALB/c and DBA/2 mice were infected by Plasmodium yoelii 17XNL and 17XL strains, respectively, and then treated with different doses of antimalarial drugs: chloroquine (228mg/kg or 114mg/kg of the body weight) or artesunate (78mg/kg or 39mg/kg). The effect of antimalarial drugs on host immune responses was evaluated by parasitemia, splenocyte IFN-gamma production level, and parasite-specific IgG level in the serum, however, no significant differences were observed between drug-treated and untreated groups. Moreover, most of the infected mice of all groups showed the ability to resist homologous reinfection (challenged on day 60 post-infection), only a few mice experienced transient, low parasitemia. The rechallenged mice were accompanied by high level of parasite-specific IgG. Therefore, this research implicated that, for BALB/c and DBA/2 mice, chloroquine or artesunate treatment of blood-stage P. yoelii infections does not compromise acquired immunity to malaria in either primary infection or upon rechallenge.
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| Authors | Shi-Hong Ma, Li Zheng, Ying-Jie Liu, Sheng-Yu Guo, Hui Feng, Guang Chen, Dong-Mei Li, Ji-Chun Wang, Ya-Ming Cao |
| Journal | Experimental parasitology (Exp Parasitol) Vol. 116 Issue 3 Pg. 266-72 (Jul 2007) ISSN: 0014-4894 [Print] United States |
| PMID | 17336298 (Publication Type: Journal Article) |
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