EANM procedure guideline for radio-immunotherapy for B-cell lymphoma with 90Y-radiolabelled ibritumomab tiuxetan (Zevalin).

Abstract

BACKGROUND:

In January 2004, EMEA approved 90Y-radiolabelled ibritumomab tiuxetan, Zevalin, in Europe for the treatment of adult patients with rituximab-relapsed or -refractory CD20+ follicular B-cell non-Hodgkin's lymphoma. The number of European nuclear medicine departments using Zevalin is continuously increasing, since the therapy is often considered successful. The Therapy, Oncology and Dosimetry Committees have worked together in order to define some EANM guidelines on the use of Zevalin, paying particular attention to the problems related to nuclear medicine.

PURPOSE:

The purpose of this guideline is to assist the nuclear medicine physician in treating and managing patients who may be candidates for radio-immunotherapy. The guideline also stresses the need for close collaboration with the physician(s) treating the patient for the underlying disease.

• Authors: Jan Tennvall, Manfred Fischer, Angelika Bischof Delaloye, Emilio Bombardieri, Lisa Bodei, Francesco Giammarile, Michael Lassmann, Wim Oyen, Boudewijn Brans, Therapy Committee, EANM, Oncology Committee, EANM, Dosimetry Committee, EANM
• Journal: European journal of nuclear medicine and molecular imaging (Eur J Nucl Med Mol Imaging) Vol. 34 Issue 4 Pg. 616-22 (Apr 2007) ISSN: 1619-7070 [Print] Germany
• PMID: 17323056 (Publication Type: Journal Article, Practice Guideline)

Chemical References

• Antibodies, Monoclonal
• Radiopharmaceuticals
• ibritumomab tiuxetan

Topics

• Antibodies, Monoclonal (therapeutic use)
• Humans
• Lymphoma, B-Cell (radiotherapy)
• Nuclear Medicine (standards)
• Practice Patterns, Physicians' (standards)
• Radioimmunotherapy (standards)
• Radiopharmaceuticals (standards, therapeutic use)