Aspirin challenge and desensitization for aspirin-exacerbated respiratory disease: a practice paper.

Abstract

Aspirin desensitization is indicated for patients who have aspirin-exacerbated respiratory disease and whose asthma and/or rhinosinusitis is suboptimally controlled with inhaled corticosteroids and leukotriene-modifying drugs. In this practice paper, the general requirements for aspirin desensitization are presented, the locations where desensitizations can be safely performed are outlined, prechallenge patient preparation is discussed, an oral aspirin challenge protocol is presented, treatment of adverse reactions is reviewed, and maintenance of aspirin desensitization is discussed.

• Authors: Eric Macy, Jonathan A Bernstein, Mariana C Castells, Sandra M Gawchik, Tak H Lee, Russell A Settipane, Ronald A Simon, Jeffrey Wald, Katharine M Woessner, Aspirin Desensitization Joint Task Force
• Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology (Ann Allergy Asthma Immunol) Vol. 98 Issue 2 Pg. 172-4 (Feb 2007) ISSN: 1081-1206 [Print] United States
• PMID: 17304886 (Publication Type: Journal Article)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Aspirin

Topics

• Anti-Inflammatory Agents, Non-Steroidal (adverse effects, immunology, therapeutic use)
• Aspirin (adverse effects, immunology, therapeutic use)
• Asthma (chemically induced, drug therapy, prevention & control)
• Desensitization, Immunologic
• Drug Hypersensitivity (drug therapy, prevention & control)
• Humans
• Rhinitis (chemically induced, drug therapy, prevention & control)
• Sinusitis (chemically induced, drug therapy, prevention & control)