Abstract | OBJECTIVES: DESIGN AND METHODS: RESULTS: Serum TAC, paraoxonase and arylesterase activities were significantly lower in BTM subjects than controls (for all p<0.001), while TOS, LOOH levels and OSI were significantly higher (p<0.001, p<0.05 and p<0.001; respectively). In BTM subjects, OSI, TOS, LOOH levels and TAC were significantly correlated with serum paraoxonase (r=-0.245, p<0.05; r=-0.231, p<0.05; r=-0.264, p<0.05 and, r=0.342, p<0.05, respectively) and arylesterase activities (r=-0.332, p<0.05, r=-0.308, p<0.05; r=-0.320, p<0.05 and r=0.443, p<0.05). Additionally, hemoglobin level was also correlated with serum paraoxonase (r=0.501, p<0.001) and arylesterase activities (r=0.501, p<0.001), TAC (r=0.402, p<0.05), TOS (r=-0.274, p<0.05) and OSI (r=-0.352, p<0.05). CONCLUSIONS: Oxidative stress is increased, while serum PON1 activity is decreased in BTM subjects. Decrease in PON1 activity seems to be associated with both the degree of oxidative stress and anemia. BTM subjects may be more prone to development of atherogenesis due to low serum PON1 activity.
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Authors | Sahbettin Selek, Mehmet Aslan, Mehmet Horoz, Mustafa Gur, Ozcan Erel |
Journal | Clinical biochemistry
(Clin Biochem)
Vol. 40
Issue 5-6
Pg. 287-91
(Mar 2007)
ISSN: 0009-9120 [Print] United States |
PMID | 17296173
(Publication Type: Journal Article)
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Chemical References |
- Antioxidants
- Lipid Peroxides
- Lipids
- Carboxylic Ester Hydrolases
- arylesterase
- Aryldialkylphosphatase
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Topics |
- Adult
- Antioxidants
(metabolism)
- Aryldialkylphosphatase
(blood, chemistry)
- Atherosclerosis
(blood)
- Carboxylic Ester Hydrolases
(blood)
- Female
- Humans
- Lipid Peroxides
(blood)
- Lipids
(blood)
- Male
- Oxidation-Reduction
- Oxidative Stress
- beta-Thalassemia
(blood)
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